Creo granted foundational patent for production of cannabinoids

Creo granted foundational patent covering advantaged method of producing GPP, an essential precursor for all cannabinoids production in fermentation.

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Biotechs are betting millions on unlocking the $115 billion synthetic-cannabis market


A handful of biotechs are raising and spending millions in a bet that they don't need to grow finicky cannabis plants to produce the valuable compounds they contain.

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Is the mainstream ready?


As more data unlocks the power of the endocannabinoid system [in the human body], we are discovering increased opportunities from minor cannabinoids such as CBG…


Creo collaborates to launch first bio-CBG skin care products on the market

Creo announces collaborations with Fifth & Root and Joiya to launch the first bio-CBG skincare products on the market

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Creo welcomes Eitan Popper

Cannabis industry pioneer Eitan Popper joins Creo as strategic adviser and investor.

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Creo collabs for new bio-CBG skincare products


Creo announces a collaboration with Fifth & Root and Joiya for bio-CBG skin care

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Creo announces new bio-CBG skincare partnerships


Creo to collaborate with Fifth & Root and Joiya for innovative new bio-CBG skicare products

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Cannabinoids drug maker GW to be acquired


Jazz Pharmaceuticals has agreed to acquire GW Pharmaceuticals, maker of the first epilepsy drug derived from the marijuana plant, for $6.7 billion in cash and stock.

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Flavor and fragrance is embracing biotech


ASF said biotechnology is its answer to meeting rising demand for natural ingredients while avoiding the pitfalls of sourcing plant-based substances.

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Creo announces collaboration on CBG


Creo announces collaborations with Fifth & Root and Joiya to bring innovative bio-CBG skincare products to market

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Creo inks CBG supply partnerships


Ingredient company Creo, whose proprietary platform is designed to product natural cannabinoids without the cannabis plant, has inked two partnerships

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Why cannabinoids are here to stay


Far from being a fad, cannabinoids stand to have profound effects on the way we make and market hundreds of consumer products.

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Creo achieves production of CBGA


A Southern California ingredient company has achieved demonstration-scale production of cannabigerolic acid (CBGA), a minor cannabinoid.

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Cool cannabinoids captivate Creo


The latest news on cannabinoids, how some are making cannabinoids without even using the cannabis plant.

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Company demos commercial process for CBG and CBGA


“Biosynthesis has progressively been replacing compounds originally derived from plants…This will be the future of how we produce many compounds.”

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Frequently asked questions

Creo is an ingredient company that produces rare and novel cannabinoids using the age-old natural process of fermentation, coupled with cutting-edge technological innovation. Creo has a platform for producing cannabinoids as ingredients developed exclusively with its joint venture partner, biotech industry leader Genomatica. Creo’s partner has successfully commercialized fermentation-based processes for plastics, cosmetics and apparel. Creo has the technology to deliver a reliable, high-quality and consistent supply of cannabinoid ingredients at commercial scale.

Creo was formed and continues to be based in the US, with headquarters in Southern California.

Creo’s mission is to enable the creation of cannabinoid products that help people everywhere while doing less harm to the planet.

Creo’s brand is built on three core pillars: sustainable innovation, access to abundance and being a trusted partner to customers. Creo makes its cannabinoid ingredients using one of the world’s oldest natural processes - fermentation. Fermentation requires less water, energy and land than the plant-based approaches typically used to extract cannabinoid ingredients. This gives Creo the ability to support the development of innovative new products without causing unnecessary harm to the planet. Creo’s ingredients are of the very highest quality, containing none of the contaminants often associated with plant-derived ingredients.

Cannabinoids are molecules that interact with the body’s endocannabinoid system (ECS). Phytocannabinoids are those cannabinoids that occur naturally in plants, most commonly the cannabis plant. THC and CBD are the most common phytocannabinoids but there are over 100 additional phytocannabinoids that have been identified. The body also produces its own cannabinoids known as endocannabinoids.

The endocannabinoid system (ECS) within the human body is made up of cannabinoid receptors and endocannabinoids. The receptors are located throughout the body including in the brain, nervous system, skin, immune cells, bone, fat tissue, blood vessels and various organs. The ECS is involved in the regulation of pain, stress, inflammation, appetite, energy, cardiovascular function, reward, sleep and other processes.

CBG, sometimes called the “mother cannabinoid” or “skin cannabinoid,” is the parent molecule from which other cannabinoids are made in the cannabis plant. But since it’s mostly converted into other cannabinoids, such as THC and CBD, very little of it remains intact in the plant (typically <0.5% by weight). Due to its scarcity, up until now, customers and patients have struggled to access the benefits of this important non-intoxicating cannabinoid. Plant cannabinoids are naturally produced in the acid form. Prior to consumption, they are typically converted into their non-acid form (“decarboxylated”) by heating. In this way, CBG is made from CBGA.

Scientific research

There is a growing body of exciting scientific research into CBG, both on its own as well as in combination with other cannabinoids. Areas of research include:

  • Antibacterial (e.g. MRSA, dental plaque)
  • Dry skin
  • Skin inflammation
  • GI inflammation
  • Neuroinflammation and neurodegeneration
  • Insulin resistance
  • Ocular tension
  • Loss of appetite
  • Mood disorders
  • Neuropathic pain

Plant extraction presents a number of challenges and uses large amounts of land, water and often electricity. Additionally:

  • Plant extracts have variable consistency
  • Cultivated plants are prone to contamination and impurities
  • Presence of THC creates regulatory complications
  • Plant extraction is impractical and expensive for rarer cannabinoids
  • Only seasonal availability

The process Creo has developed provides pure, consistent, single molecules that it can produce at scale, contaminant free, with a smaller environmental footprint all year round.

No. Through Creo’s fermentation process it produces natural CBG without the use of the cannabis plant.

Yes, there are more than 100 cannabinoids known in the plant but only two are currently being actively exploited (THC & CBD). Creo specializes in producing a wide variety of rare and novel cannabinoids, beginning with CBG (Cannabigerol).

Creo’s technology and process are patented and proprietary with freedom-to-operate, so customers can rely on Creo to be a trusted supplier.

Creo’s products are manufactured and packaged in an FDA registered food grade facility in the US.

Press kit

Creo, a cannabinoid ingredient company, set to disrupt industry amid launch with proprietary process & technology.


Press kit

Creo, a cannabinoid ingredient company, set to disrupt industry amid launch with proprietary process & technology.


Press kit

Creo, a cannabinoid ingredient company, set to disrupt industry amid launch with proprietary process & technology.